In this paper we report a mid-infrared sensor based on an anti-resonant hollow core fiber. A quantum cascade laser operating around 4.53 µm is used to target one of the strongest transition of nitrous oxide near 2203.7 cm−1. The system provides 1-second minimum detection limit at single parts-per-billion level using 3.2-m-long fiber with the response time of less than 30 seconds. Presented sensing approach shows a good perspective for compact and sensitive mid-infrared fiber-based spectrometers.