High-quality seismic data on the lower crust and uppermost lithospheric mantle in the Central European part of the Trans European Suture Zone, together with thermal and gravimetric data, enables the quantitative modeling of the rocks occurring in those parts of the lithosphere, including their mineral compositions and the chemical composition of individual minerals. The P3 seismic profile is located at the SW margin of the East European Craton. The lower crust is dominated by gabbronoritic intrusions (plagioclase An45Ab55, clinopyroxene Di80Hed20, orthopyroxene En74Fs26), and the uppermost mantle is harzburgitic (olivine and orthopyroxene Mg# 0.91). The lower crust and upper mantle of the P1 seismic profile belong to the Trans European Suture Zone, albeit the upper crust is of Variscan affinity. The P1 lower crust has gabbronoritic composition which is layered from plagioclase-rich compositions on the top to the orthopyroxene-rich ones at the bottom (plagioclase An45Ab55, clinopyroxene Di80Hed20, orthopyroxene En85Fs15), and is lithologically different Proterozoic and Variscan surroundings. The 100 × 200 km eclogite slice (garnet Alm48Gr25Py27, clinopyroxene Di51Hed10Jd39), with a thickness of 5–10 km, occurs in the uppermost mantle sampled by the P1 profile. The Niedźwiedź Massif is located at the NE margin of the Bohemian Massif, which shows an exposed Variscan basement. The lower crust beneath the Niedźwiedź Massif consists of gabbroic rock of variable proportions of plagioclase (An45Ab55) and clinopyroxene (Di80Hed20), whereas the uppermost mantle is supposedly spinel harzburgite (olivine, ortho- and clinopyroxene Mg# 0.90). Our models show that the lowermost crust and uppermost mantle of the East European Craton do not continue to the SW into the Trans European Suture Zone in its Central European section in Poland.