This paper presents a full-wave electromagnetic analysis of soft-glass photonic crystal fibers developed for the generation of supercontinuum based on third-order nonlinearity. It is shown that a two-dimensional finite-difference time-domain method for guided problems provides results very similar to the measurement data of real fiber structures, enabling the reduction of costly hardware prototyping, thus, opening the way for the application of FDTD to the modeling of nonlinear optical processes.